Analysis of cartilage oligomeric matrix protein (COMP) in synovial fibroblasts and synovial fluids
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منابع مشابه
Analysis of cartilage oligomeric matrix protein (COMP) in synovial fibroblasts and synovial fluids.
We investigated the expression of cartilage oligomeric matrix protein (COMP) in normal and rheumatoid arthritis (RA) synovial fibroblasts. In situ hybridization (ISH) was conducted on synovial specimens from five RA patients applying specific probes for COMP or fibroblast collagen type I. ISH was combined with immunohistochemistry, applying antibodies to the macrophage marker CD68. Ribonuclease...
متن کاملGalectin-3 is induced in rheumatoid arthritis synovial fibroblasts after adhesion to cartilage oligomeric matrix protein.
BACKGROUND Galectin-3 is expressed in the synovial tissue of patients with rheumatoid arthritis (RA), particularly at sites of joint destruction. OBJECTIVE To explore the possibilities that galectin-3 is induced either by proinflammatory cytokines or by adhesion to cartilage components. METHODS Cell culture plates were coated with fibronectin, collagens I-VI, or cartilage oligomeric matrix ...
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Arthritis is a chronic disease with a significant impact on the population. It damages the cartilage, synovium, and bone of the joints causing pain, impairment, and disability in patients. Current methods for diagnosis of and monitoring the disease are only able to detect clinical manifestations of arthritis late in the process. However, with the recent onset of successful treatments for rheuma...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 1998
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/37.7.721